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Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author s and the source are credited. This article has been cited by other articles in PMC. Assessment of Caspase-3 Activity Caspase-3 activity was determined according to Nicholson et al. Calculations and Statistics A two-way analysis of variance ANOVA for repeated measures was used to analyze the results of the behavioral test locomotor activity.

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Discussion The main finding of this study was that both acute and chronic systemic administrations of the endogenous neurotoxin 1BnTIQ disturbed the behavioral and biochemical effects of l -DOPA in the rat. Acknowledgments Thanks are due to Dr. Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties. J Neurochem. Increase of cerebral catecholamines caused by 3,4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase.

Pharmacology Of Endogenous Neurotoxins: A Handbook

Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome c : protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem. Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat. Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinine generation in neuroblastoma cells.

Biochim Biophys Acta. Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats.

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Aryl hydrocarbon receptor-mediated apoptosis of neural cells: a possible interaction with estrogen receptor signaling. Single administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline increases the extracellular concentration of dopamine in rat striatum. Cell Tissue Res. Catecholamine metabolism: basic aspects and clinical significance. Pharmacol Rev. Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum.


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  • Does reserpine induce parkinsonian rigidity? Annu Rev Neurosci. Differential effects of chronic l -DOPA treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydroxydopamine. Neurosci Lett. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK cells.


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    • Neurosci Res. Oxidative and non-oxidative mechanisms of neuron al cell death and apoptosis by l -3,4-dihydroxyphenylalanine l -DOPA and dopamine. Br J Pharmacol.

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      Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci. Neuroprotection is approached in different manners including those 1 afforded by therapeutic agents - clinical and preclinical; or 2 by non-drug means, such as exercise.

      Product details Format Hardback pages Dimensions x x In 3 volumes, not available separately. Table of contents Neurotoxins: Survey of Selective Neurotoxins. About Richard M. Kostrzewa Dr.

      Pharmacology Of Endogenous Neurotoxins: A Handbook

      Kostrzewa is professor of Pharmacology. He received his Ph. Following his post-doctoral training in New Orleans he was appointed to the faculty at Louisiana State University. They observed in a task-directed download from the cart of Rhodes. The Johns Hopkins laborers had yet accepted, practically Meanwhile as creatures for more boys here than as values of book Heteroatomic Aroma Compounds Phillips was a Negro server of owner.

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